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Alzheimers Disease

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Submitted By geenjokie
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Targeting Insulin Signaling in Treating Alzheimer’s Disease
Name
Institution Table of Contents
Abstract 3
Summary 4
Introduction 5
Present Therapeutic Regimens for Alzheimer’s disease 5
Methods 7
Search Strategy 7
Exclusion/ Inclusion Criteria 8
Relevant Information 8
Results 9
Discussion of Results 12
Epidemiological information linking type 2 diabetes to AD 16
Insulin-signaling abnormalities in Alzheimer disease affected brain 17
Diabetes drugs in treatment for AD 19
Treatments regimens for type 2 diabetes Mellitus and their potential in treating AD 23
Thiazolidinediones (TZDs). 23
Metformin. 23
Amylin and Leptin analogs. 24
Findings 26
Interpretation of Results 26
Limitations 28
Future Research 29
Conclusion 31
References 32

Abstract
Type 2 diabetic drugs could serve as potential in the treating Alzheimer’s disease. AD is a dementia defined by partial or total loss of memory. The risk of development of AD increases with age. Different therapeutic approaches have been employed when it comes to treatment of AD. Results of indicate that diabetic drugs are effective in treating Alzheimer ’s disease.
Despite efforts directed at treatment of the condition, the results have not been satisfactory. This could be attributed to the early or late onset of AD pathogenesis while at the same time being underpinned by various mechanisms. There is evidence suggesting the effectiveness of type 2 diabetic drugs in treatment of AD. Research has focused on understanding the possibility of using Type 2 diabetic drugs in the treatment of AD.
In this paper, a research review is conducted to expand on the potential use of T2DM diabetic drugs in treating AD. A literature review is being carried out on different papers written by authors. A systematic literature review is conducted where results they obtained and a discussion carried out on the same.…...

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