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In: People

Submitted By wcramer
Words 1736
Pages 7
Oral and Maxillofacial Pathology
April 28, 2016

Chronic Inflammation and Wound Repair

Mark A. Lerman, D.M.D.
Associate Professor and Division Director of Oral Pathology
Tufts University School of Dental Medicine

• Introduction
• Acute inflammation
– Vascular changes
– Cellular events
– Hereditary defects

• Chronic inflammation
– Cellular mediators
– Granulomatous inflammation

• Tissue Repair

• Chronic inflammation
– Cellular mediators
– Granulomatous inflammation

• Tissue repair
– Cell and tissue regeneration
– Scar formation
– Factors influencing repair

Chronic Inflammation
• Inflammation of prolonged duration
– Continuing inflammation
– Tissue injury
– Healing

Chronic Inflammation
• Characterized by
– Lymphocytes, plasma cells, and macrophages – Tissue destruction
– Repair

Chronic Inflammation
• Arises in setting of
– Persistent infections
• Treponema pallidum
• Mycobacterium, viruses, and fungi

– Immune-mediated disease
• Hypersensitivity reactions
• Autoimmune diseases

– Prolonged exposure to toxins
• Silica
• Crystal

Dominant cells of chronic inflammation
Tissue cells derived from blood monocytes Fusion of activated macrophages forms multinucleated giant cells
Mononuclear phagocyte system
(reticuloendothelial system) includes cells scattered in connective tissue, liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), CNS
(microglial cells), and lungs (alveolar macrophages) Macrophages
Activated by either classical (induced by microbial products, cytokines, or foreign material) or alternative (other cytokines or other cells including mast cells and eosinophils) pathways

• Roles in host defense and inflammatory response – Phagocytosis
– Tissue repair
– Secretion of mediators…...

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